Age-related Macular Degeneration

Uveitis is inflammation of the uvea, the middle layer of the eye between the retina and the sclera (white of the eye). The eye is shaped like a tennis ball, with three different layers of tissue surrounding the central gel-filled cavity. The innermost layer is the retina, which senses light and helps to send images to your brain. The outermost layer is the sclera, the strong white wall of the eye. The middle layer between the sclera and retina is called the uvea.  
The uvea contains many blood vessels — the veins, arteries and capillaries — that carry blood to and from the eye. Because the uvea nourishes many important parts of the eye (such as the retina), inflammation of the uvea can damage your sight.  

There are several types of uveitis, defined by the part of the eye where it occurs.  

• Iritis affects the front of your eye. Also called anterior uveitis, this is the most common type of uveitis. Iritis usually develops suddenly and may last six to eight weeks.
• If the uvea is inflamed in the middle of the eye, it is called pars planitis (or intermediate uveitis). Episodes of pars planitis can last between a few weeks to years. The disease goes through cycles of getting better, then worse.
• Posterior uveitis affects the back of your eye. Posterior uveitis can develop slowly and often lasts for many years.
• Panuveitis occurs when all layers of the uvea are inflamed. The specific cause of uveitis often remains unknown. In some cases, however, it can be associated with other disease or infection in the body.

Uveitis may be associated with:

• A virus, such as shingles, mumps or herpes simplex.
• Systemic inflammatory diseases.
• An injury to the eye.
• A fungus, such as histoplasmosis or a parasite, such as toxoplasmosis.

If you smoke, stop. Studies have shown that smoking contributes to the likelihood of developing uveitis. 
Uveitis may develop suddenly with eye redness and pain, or with a painless blurring of your vision. In addition to red eye and eye pain, other symptoms of uveitis may include light sensitivity, blurred vision, decreased vision and floaters. There may also be a whitish area (called a hypopyon) inside the lower part of the iris.

Your ophthalmologist will examine the inside of your eye. He or she may order blood tests, skin tests or X-rays to help make the diagnosis.   Uveitis is a serious eye condition that may scar the eye. It needs to be treated as soon as possible. Eyedrops, especially corticosteroids and pupil dilators, can reduce inflammation and pain. For more severe inflammation, oral medication or injections may be necessary.

If left untreated, uveitis may lead to:

• Glaucoma (increased pressure in the eye).
• Cataract (clouding of the eye's natural lens).
• Neovascularization (growth of new, abnormal blood vessels).
• Damage to the retina, including retinal detachment.

These complications may also need treatment with eye drops, conventional surgery or laser surgery.